In this article, we show that conolidine, a organic analgesic alkaloid used in standard Chinese drugs, targets ACKR3, thus delivering more evidence of the correlation concerning ACKR3 and soreness modulation and opening alternate therapeutic avenues for that procedure of chronic discomfort. Utilized in standard Chinese, Ayurvedic, and Thai medicine. https://charlesi690qyq2.wikigop.com/user