There is a release of norepinephrine within the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors from the dorsal horn to minimize afferent discomfort transmission and make analgesia. Hence, medications like clonidine that focus on alpha-2 receptors can impact the transmission of pain. Relates to clonidine: oral pill, oral https://paulf395dtk0.jts-blog.com/profile