While in the LSD-sure crystal construction, the side chain with the lid residue L209EL2 types in depth hydrophobic contacts with equally LSD and surrounding residues in TMs III, IV, and V (Figure 4C). When the lid moved apart to expose the binding pocket in simulation, many of such contacts broke. https://socialrus.com/story19984386/an-unbiased-view-of-fractal-storm-self-laid